Nicolsamide mbadamba
Niclosamide bụ salicylanilide salicylanilide chlorinated nke a na-enweta n'ọnụ, nwere ọrụ anthelmintic na ike antineoplastic.Mgbe nchịkwa ọnụ, niclosamide na-ebute kpọmkwem mmebi nke androgen receptor (AR) variant V7 (AR-V7) site na ụzọ mgbasa ozi proteasome.Nke a na-eweda okwu nke AR dị iche iche, na-egbochi ọrụ mgbasa ozi mgbasa ozi AR-V7, ma na-ebelata mbanye AR-V7 na prostate-specific antigen (PSA) gene akwalite.Niclosamide na-egbochikwa AR-V7 nke STAT3 phosphorylation na ịgbalite phosphorylation na ịgbalite.Nke a na-egbochi mgbasa ozi mgbasa ozi AR/STAT3 ma gbochie nkwupụta mkpụrụ ndụ ihe nketa STAT3.N'ozuzu, nke a nwere ike igbochi uto nke AR-V7-na-egosipụta oke mkpụrụ ndụ kansa.Ihe dị iche iche nke AR-V7, nke etinyere ya site na mwepu nke AR exons 1/2/3/CE3, na-ahazi n'ụdị mkpụrụ ndụ kansa dị iche iche, yana njikọ ya na ọganihu ọrịa kansa yana iguzogide ọgwụgwọ ezubere iche maka AR.
Ihe mejupụtara:
Nke ọ bụla bolus cotnains 1250 mg niclosamide
Ngosipụta:
Maka anu na-ebute ọrịa paramphistomes, cestodiasis, dị ka ehi na atụrụ moniezia, avitellina centripunctata, wdg.
Usoro onunu ogwu na ojiji:
Ọnụ nke ọ bụla 1kg arọ ahụ.
Anụ: 40-60mg
Atụrụ: 60-70mg
Oge mwepụ:
Atụrụ: ụbọchị 28.
Anụ: ụbọchị 28.
Nha ngwugwu: mbadamba 5 kwa ọnya, ọnya blister kwa igbe
